Axiron is a solution of testosterone that is administered through the skin of the armpit for treatment of low testosterone levels. It belongs to a class of drugs called androgens. Other testosterone replacement products include Androderm , Androgel , Testim, and Fortesta. Testosterone is the major male sex hormone responsible for the normal growth and development of the male sex organs and secondary sex characteristics. These effects include development of the prostate, penis and scrotum; distribution of facial, pubic, chest and axillary hair; development of a deep voice and alterations in muscle mass and fat distribution. Low production of testosterone leads to erectile dysfunction , reduced sexual desire, fatigue and loss of energy, depression , regression of secondary sexual characteristics and weakening of bones ( osteoporosis ). Testosterone replacement products supplement or replace natural production of testosterone and reverse symptoms of low testosterone levels. The FDA approved Axiron in November 2010.