Oxytocin is distributed throughout the extracellular fluid. Small amounts of the drug probably reach the fetal circulation. Oxytocin has a plasma half-life of about 1 to 6 minutes which is decreased in late pregnancy and during lactation. Following intravenous administration of oxytocin, uterine response occurs almost immediately and subsides within 1 hour. Following intramuscular injection of the drug, uterine response occurs within 3 to 5 minutes and persists for 2 to 3 hours. Its rapid removal from plasma is accomplished largely by the kidney and the liver. Only small amounts are excreted in urine unchanged.
Jennifer E. Dubas is Senior Vice President and Chief Compliance Officer, effective October 2016. In this role, she is responsible for the strategic direction and operations of Endo’s corporate compliance program. Ms. Dubas joined Endo in 2011 and has been a valued member of Endo’s Legal leadership team, previously serving as Endo’s Senior Vice President, Associate General Counsel where she was responsible for managing all non-IP, non-employment litigation for Endo and its subsidiaries. In 2015, she accepted the additional responsibility of managing the legal support for Endo’s . Branded Pharmaceutical business. In this role, in addition to advising the business on legal matters, Ms. Dubas also provided legal support to Endo’s Compliance organization, including the advising on the successful management of Endo’s 2014 Corporate Integrity Agreement (CIA) and Deferred Prosecution Agreement (DPA). She has spent her 16 year legal career providing effective advice to pharmaceutical, medical device and consumer products companies. Ms. Dubas began her professional career as an associate in Dechert’s litigation group where she represented various pharmaceutical and consumer product companies. In 2005, Ms. Dubas joined Wyeth’s in-house litigation team and then served in a similar capacity for Pfizer, following its acquisition of Wyeth. She holds a Juris Doctor degree, magna cum laude, from Temple University, and a Bachelor of Arts degree, magna cum laude, from Bryn Mawr College.