Meta-analyses of placebo-controlled trials suggest that testosterone therapy in physiological doses is significantly associated with increased haematocrit, reduced high-density lipoprotein cholesterol and prostatic symptoms. 29 , 30 If prostate cancer has been excluded, there appears to be no increased risk of induction by testosterone therapy. There is inconsistent evidence regarding the risk of cardiovascular events. 29-31 A recent meta-analysis suggested increased cardiovascular risk and reported publication biases. 32 Long-term safety data are lacking, but recent reports more strongly suggest an increased risk of cardiovascular events in older men. 3 , 4 This has prompted the Endocrine Society to issue a warning statement. 5 The results and safety of long-term prospective controlled trials of testosterone therapy are awaited.
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Testosterone is a sex hormone; It is naturally produced in both men and women but is made at a much higher level in men. Low testosterone is not just about libido or becoming stronger and bigger in the gym. While this can be an effect of treatment, the condition known as Low T is much more in-depth. It is what gives a male the secondary sex characteristics of a man. Testosterone – which can profoundly reduce energy levels – is responsible for stimulating muscle growth, achieving normal erectile and cognitive functions, restore energy levels and maintaining normal bone density.