The effect of a nutritional source of tryptophan on dieting-induced
changes in brain 5-HT function.
Psychol Med. 2003.
Dieting in healthy women results in a decrease in the availability of tryptophan, the amino-acid precursor of serotonin, for brain serotonin synthesis. This is associated with increases in the prolactin response to serotonin drug challenge suggesting a 'supersensitivity' of serotonin neuroendocrine responses. The aim of the study was to assess whether increased tryptophan intake during dieting would prevent the changes in tryptophan availability and serotonin neuroendocrine function. Fifty female subjects underwent a 1000 kcal daily diet for 3 weeks. In the final week of the diet subjects were randomly allocated to receive either nutritionally-sourced tryptophan ( g daily) or placebo in a double-blind, parallel group, design. Tryptophan supplementation failed to modify the dieting-induced reduction in fasting tryptophan availability to the brain. However, in contrast to placebo-treated subjects, subjects receiving additional tryptophan did not show enhanced prolactin responses to intravenous tryptophan challenge. The decrease in tryptophan availability produced by dieting may be due to increased tryptophan metabolism rather than decreased tryptophan intake. While tryptophan treatment did not increase fasting tryptophan availability it may have modified the effect of dieting on brain serotonin function. Further studies will test the effect of tryptophan has consequences for the effectiveness of dieting as means of weight control.
Hi Alicia. How often are you feeding? Just wanted to check if you are breastfeeding your baby often and if your baby is gaining weight. If your supply is really low, have you also consulted your doctor if fenugreek is good for you? Need to ask to be certain that you do not have any sensitivities to fenugreek. If your doctor has cleared you, and while all the supplements I mentioned are safe, I would personally recommend the Traditional Medicinals Organic Mothers Milk Tea . While it is helpful in increasing milk supply, please check that you do not have any allergies in the parsley family and daisy family before you take it.