Ultimately, the goal with any medical treatment is to reduce mortality and increase longevity. As of this writing, two prospective studies have demonstrated reduced mortality in men treated with testosterone. 20 , 39 In a study of 1031 men, testosterone treatment was initiated in 398 men (39%) during routine clinical care. 20 After a follow-up of 20 months, mortality was 21% among untreated men versus 10% among testosterone treated men, with the greatest mortality reduction in younger men and those with type 2 diabetes. 20 The second study of 587 men with type 2 diabetes had a follow-up of years. 51 men were treated with testosterone for 2 years or more (mean testosterone therapy duration years). Mortality rate was 20% in untreated hypogonadal diabetic men and % in hypogonadal diabetic men who received testosterone therapy. 39 Both of these studies show that testosterone therapy reduces death by half and increases longevity in treated men.
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